Research Networks
WIRE collaborates with institutions across the globe through formal research networks and consortia.
45+
Institutions
42
Cities
8
Countries
312+
Co-pubs
Northwestern
Chicago, IL
MUSC
Charleston, SC
Ohio State
Columbus, OH
U of Colorado
Aurora, CO
Harvard / BCH
Boston, MA
Baylor / TCH
Houston, TX
Case Western
Cleveland, OH
U of Pittsburgh
Pittsburgh, PA
CHOP / Penn
Philadelphia, PA
U of Iowa
Iowa City, IA
Wash U
St. Louis, MO
Johns Hopkins
Baltimore, MD
Yale
New Haven, CT
U of Michigan
Ann Arbor, MI
UAB
Birmingham, AL
U of Calgary
Calgary, AB
SickKids
Toronto, ON
CHEO
Ottawa, ON
McGill
Montreal, QC
Sapienza
Rome, Italy
Showing top 20 of 45+ institutional partners across 42 cities in 8 countries
Networks & Consortia
The RESUME trial is a large, multicenter, randomized, comparative effectiveness study investigating the optimal timing for resuming direct oral anticoagulants (DOACs) after high-risk gastrointestinal endoscopy. The study aims to address a critical gap in evidence, balancing the risk of delayed GI bleeding with the risk of thromboembolic events, in a growing population of patients taking DOACs who require endoscopic procedures.
Main Purpose
Determine whether delaying DOAC resumption after high-risk endoscopy reduces clinically significant GI bleeding without a significant increase in thromboembolic risk.
Principal Investigator
Zachary Smith, DO, MSc
Funding
Pending
Network Sites
The Stents Versus Indomethacin (SVI) trial was a landmark, multicenter, randomized, double-blind, non-inferiority trial evaluating whether rectal indomethacin alone is as effective as the combination of rectal indomethacin plus prophylactic pancreatic stent placement for preventing pancreatitis after high-risk ERCP. The trial established that indomethacin alone was not as effective as the combined strategy, supporting current guideline recommendations to use both interventions in high-risk cases. The SVI Study Group continues to collaborate on impactful research, including post hoc SVI analyses and other impactful endoscopic research.
Main Purpose
To determine whether prophylactic pancreatic stent placement provides additional benefit over rectal indomethacin alone in preventing post-ERCP pancreatitis among high-risk patients.
Principal Investigator
B. Joseph Elmunzer, MD, MSc (Medical University of South Carolina)
Funding
National Institutes of Health (NIDDK), grant U01DK104833
Network Sites
The Large Polyp Study Group is a collaborative research network conducting multiple high-impact studies on advanced endoscopic resection techniques for large colorectal polyps. Their hallmark work — a large, multicenter randomized controlled trial comparing cold snare EMR and hot EMR for large colon polyps — was ultimately published in Gut and is regarded as a major contribution to the field. The group continues to collaborate on innovative, practice-changing EMR research across diverse academic centers.
Main Purpose
To advance the safety, efficacy, and technique of endoscopic mucosal resection (EMR) for large colorectal polyps through multicenter, collaborative research.
Principal Investigator
Heiko Pohl, MD
Funding
Supported by research grants from STERIS and Cosmo Pharmaceuticals
Network Sites
The CAN Resect Study Group is a collaborative research network uniting leading centers across the US and Canada to advance the safety and efficacy of endoscopic mucosal resection (EMR) for large colorectal polyps. The group conducts multicenter, randomized trials that address the most pressing clinical questions in polyp resection, including innovations in non-thermic techniques, prevention of recurrence, and the role of adjuvant therapies. Its studies are shaping guidelines and best practices for endoscopic management of large polyps.
Main Purpose
To compare innovative EMR techniques — such as non-thermic EMR and adjuvant thermal ablation — for large colorectal polyps, aiming to reduce recurrence and adverse events while improving cost-effectiveness and patient safety.
Principal Investigator
Daniel von Renteln, MD (CHUM, Montreal)
Funding
Supported by the Canadian Institutes of Health Research (CIHR)
Network Sites
The Calgary Registry for Advanced and Therapeutic Endoscopy (CReATE) is a prospective, multi-center registry designed to capture detailed clinical, technical, and outcome data for ERCP procedures performed across leading Canadian centers. CReATE serves as a foundational data platform for high-impact studies on ERCP effectiveness, safety, risk factors for adverse events, and training outcomes, ultimately aiming to improve the quality and value of endoscopic care.
Main Purpose
To systematically collect and analyze data on ERCP procedures in order to better understand clinical effectiveness, patient outcomes, risk factors for adverse events, and the impact of educational practices in advanced endoscopy.
Principal Investigator
Nauzer Forbes, MD, MSc (University of Calgary)
Funding
Intramural
Network Sites