A clinical research lab at the Medical College of Wisconsin leading the future of endoscopic evidence generation.
Our Mission
WIRE is dedicated to improving patient outcomes by generating the evidence that shapes endoscopic practice. Through methodologically rigorous, multicenter research we bridge the gap between clinical questions and actionable answers.
Research Excellence
Generating high-quality procedural evidence through rigorous study design, transparent methodology, and reproducible results.
Global Network
Partnering with institutions across the globe to conduct large-scale, multicenter studies that shape clinical practice worldwide.
Collaboration
Leveraging a diverse multidisciplinary expertise and broad institutional resources to tackle important questions in endoscopy.
Recent Publications
Our latest peer-reviewed publications from PubMed.
Research Highlights
Featured projects of the current WIRE portfolio
RESUME
A large, multicenter, adaptive randomized trial comparing early, intermediate, and delayed DOAC resumption strategies after high-risk GI endoscopy. Preparing for NHLBI UG3/UH3 submission.
CORE
Core Outcomes for Research in Endoscopy — developing multi-stakeholder Core Outcome Sets, hierarchical composite endpoints, and operator-aware analytic frameworks to modernize evidence generation in GI endoscopy.
Project Harmonize
Building standardized institutional procedural repositories to enable high-quality, structured data capture across endoscopic procedures for research and quality improvement.
RENEW
A single-center feasibility trial evaluating MyChart-based recruitment, remote e-consent, and real-time Epic-embedded randomization to validate the infrastructure for large pragmatic platform trials in GI endoscopy.
Latest News
Recent updates and announcements from the WIRE team.
Talia Malik and Dr. Dua Win Mel Schapiro Award and VideoGIE Best of the Best at DDW 2026
WIRE GI Fellow and Mentor Earn Top Video Submission Honors Out of More Than 800 Abstracts
Talia Malik, MD, a gastroenterology fellow and WIRE Mentee working under the mentorship of Dr. Kulwinder Dua, has been awarded the Mel Schapiro Award and VideoGIE Best of the Best at Digestive Disease Week 2026 for their presentation "Regrowing the Human Esophagus In Vivo with Endoscopic Bioengineering," selected from more than 800 abstract submissions.
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RESUME Patient Engagement Study Selected for Presentation at ESGE Days 2026 in Milan
Late-Breaking Abstract on Patient Preferences Informing the RESUME Trial Accepted by ESGE Scientific Committee
A late-breaking abstract led by WIRE Founding Director Dr. Zachary Smith has been selected for presentation at ESGE Days 2026 in Milan. The study examines patient preferences regarding bleeding versus thromboembolic risk after DOAC interruption for high-risk endoscopic procedures — foundational work informing the design of the RESUME trial.
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Dr. Lerner Contributes to National Delphi Consensus on Unsedated Transnasal Endoscopy Competency
WIRE Faculty Member Joins 27-Expert Panel to Develop First Validated Assessment Tool for Pediatric TNE
Dr. Diana Lerner participated in a 27-expert North American Delphi consensus study that developed the TransNasal Endoscopy Skills Assessment Tool (TNE-SAT) — the first validated, video-based instrument for assessing clinician competence in unsedated transnasal endoscopy in pediatric patients.
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